Dermatopoietin is our trade name for human interleukin-1 alpha (IL-1a). Its INCI name is sh-Polypeptide-17. IL-1a is an epidermal cytokine produced in healthy skin by keratinocytes and in hair follicles by epithelial matrix cells, respectively, on a constitutive basis. It acts as key regulator of skin renewal and hair growth.
Dermatopoietin is the key ingredient of a patented technological platform with wide applications in skin care (cosmetics, dermatology), hair care and oral care. In combination with Hexadeltine and other active ingredients this technology allows the formulation of tailored products to promote skin and hair renewal for use in cosmetics or pharmaceutics.
Dermatopoietin is a 159 amino acid protein. For application in cosmetic products it is produced by recombinant biotechnology in a prokaryotic expression system. Due to its size Dermatopoietin cannot penetrate skin. Contact with the first layer of living epidermal cells (keratinocytes) in the outer skin however triggers them to produce and release endogenous IL-1a, thus starting a signal cascade which propagates through the entire epidermis and eventually reaches the fibroblasts in the dermis. In the dermis IL-1a stimulates fibroblasts to produce collagen, elastin and hyaluronic acid and to release several growth and differentiation factors which act on the epidermis. In a similar way IL-1a stimulates dermal papilla cells in the hair follicles to stop excessive hair shedding and initiate the anagenic growth phase.
We call this mode of action of our products based on Dermatopoietin – triggering a signal cascade that penetrates deep into the skin without itself penetrating it – signalling cosmetics®.
The efficacy profile of Dermatopoietin as active ingredient in cosmetic preparations has been investigated in living skin by 2-photon fluorescence microscopy, ultrasonography and cutometry. In skin the most prominent effect of Dermatopoietin is a strong stimulation of collagen deposition. This translates into a strong
- anti-aging effect (increase of skin elasticity and skin thickness, reduction of wrinkles), and
- anti-cellulite effect (smoothening of skin).
Applied on scalp Dermatopoietin acts (indirectly) on dermal papilla cells and thereby
- inhibits hair shedding, and
- promotes anagenic hair growth.
Dermatopoietin is always used in combination with Hexadeltine.
Hexadeltine is our trade name for the patented hexapeptide Tyr- D-Ala-Gly-Phe-Leu-Asp. It is a synthetically produced enkephalin analogue which has the INCI name Hexapeptide-18. As water soluble compound Hexadeltine does not penetrate skin but acts on delta opioid receptors situated on epidermal skin cells.
The pharmacological profile of Hexadeltine supports that of Dermatopoietin: Hexadeltine potentiates the response to low and curtails the response to high concentrations of Dermatopoietin, it increases the microcirculation and it inhibits the proliferation of keratinocytes, thus preventing skin keratosis.
Hexadeltine improves the efficacy and safety profile of Dermatopoietin. United Technologies UT AG owns intellectual property rights on the compound itself, its application alone and in combination with IL-1a in cosmetics and dermatology.
United Technologies UT AG owns the following patents which protect its rights on the biotechnology platform of interleukin-1 alpha (= Dermatopoietin®) and enkephalin analogues:
US Patent No 7,981,409 B2based on PCT/EP2008/054574 Publ. Nr. US 2009 0263350 A1
|A method of reducing aging of skin by applying interleukin-1 alpha||USA|
Eurasian Application No 201001599based on PCT/EP2008/054574 WO 2009/127248 A1
|Cosmetic and dermatological compositions and kits containing interleukin-1 alpha||Eurasia|
Eurasian Application No 201001598based on PCT/EP2008/055011 WO 2009/129857 A1
|Hexapeptides and compositions thereof||Eurasia|
US Patent No 8,298,523 B2based on PCT/EP2008/065152 Publ. Nr. US 2011/0189126
|Compositions containing interleukin-1 alpha and peptides||USA|
European Patent Application No 08875294.4based on PCT/EP2008/065152 WO 2010/051852 A1 Publ. Nr. 2364160
|Compositions containing interleukin-1 alpha and peptides||Europe|
Eurasian Application No 201100459based on PCT/EP2008/065152 WO 2010/051852 A1
|Compositions containing interleukin-1 alpha and peptides||Eurasia|
Ukrainian Patent Application No 2011 07126based on PCT/EP2008/065152 WO 2010/051852 A1
|Compositions containing interleukin-1 alpha and peptides||Ukraine|
Japanese Patent Application No 2011-535013based on PCT/EP2008/065152 WO 2010/051852 A1
|Compositions containing interleukin-1 alpha and peptides||Japan|
Korean Patent Application No 2011-7012572based on PCT/EP2008/065152 WO 2010/051852 A1 Divisional Application No. 2014-7008245 Published 30 May 2014 Publ. No.: 2014-66209
|Cosmetic compositions containing interleukin-1 alpha and peptide||Korea|
Mexican Patent Application No MX/a/2011/009572based on PCT/EP2009/001957
|Topical compositions comprising interleukin-1 alpha and peptides and cosmetic methods thereof||Mexico|
Chinese Patent Application No 2009801615797based on PCT/EP2009/062639 Publ. No. CN 102573788 A
|Oral care compositions containing human recombinant Interleukin-1 alpha||China|
Japanese Patent Application 2012-531243, published on 21 Feb 2013, based on PCT/EP2009/062639
|Oral care compositions containing human recombinant interleukin-1 alpha||Japan|
Korean Patent Application No 2012-7008138based on PCT/EP2009/062639 Publ. No 2012-0081593
|Oral care compositions containing human recombinant interleukin-1 alpha||Korea|
Eurasian Patent Application No 2012200196based on PCT/EP2009/062639 WO 2011/038754 A1
|Oral care compositions containing human recombinant interleukin-1 alpha||Eurasia|
Ukrainian Patent Application No 2012 05107based on PCT/EP2009/062639 WO 2011/038754 A1
|Oral care compositions containing human recombinant interleukin-1 alpha||Ukraine|
US Patent 8,603,456 B2Application No US 13/500,358 Publ. No. US-2012-0195853-A1 based on PCT/EP2009/063078 WO 2011/042056 A1
|Method of treating hair loss with compositions containing interleukin-1 alpha||USA|
Eurasian Patent Application No 201200353based on PCT/EP2009/063078 WO 2011/042056 A1
|Cosmetic method for treatment of skin and hair with cosmetic compositions containing interleukin-1||Eurasia|
Taiwanese Patent Application No 099134009based on PCT/EP2009/063078 WO 2011/042056 A1
|Use of interleukin-1 for manufacturing compositions for treating hair loss||Taiwan|
- Interleukin-1 alpha, an epidermal cytokine critical for skin renewal. I. Pomytkin, SOFW J 2009; 135: 2-6
- Synergistic peptide action revitalizes skin and hair. P. Schoch and I. Pomytkin, Personal Care – Asia Pacific 2010, June
- Skin rejuvenating effects of interleukin-1 alpha: A cosmetic study on collagen deposition and elasticity in ageing skin. I. Pomytkin and P. Schoch, Aestetics 2015, 2 (3): 39 – 41